The big matchup for me is the Patriots secondary against a new quarterback in EJ Manuel. Can they mix up enough looks to confuse a young QB? Can they contain him defensively and not let him out of pocket? The Bills offensive line vs. the Patriots defensive line will be a big matchup. Buffalo has to protect their young quarterback when he has to throw because speed of the game changes from preseason to regular season. They need make the kid see ghosts and be uncomfortable.