Very interesting question, because I do think that Ayers is a bit better in space than Chandler is. However I think Chandler is the better player on the line and really, that’s what is most important as a defensive end.
Ayers has been very good, but at the same time I think a lot of his success has been a result of scheme, not necessarily him being physically dominant. Ayers has certainly flashed levels of dominance, but I think Chandler is more capable of “ruining a game/play” by himself.
I do think, like you said, we could see a Ninkovich-Chris Jones-Chandler Jones-Ayers all-out pass rush front (sorry Easley). Chandler is a load inside and that would make for a nightmare.
It will be depend on the game plan but Ayers has shown enough to remain involved when Chandler is back to 100%. Ayers could also play some linebacker with Jones at defensive end. BB will get creative to get his best 11 out there.